CRISPR TEXNOLOGIYASI VA UNING TIBBIYOTDAGI QO'LLANILISHI
https://doi.org/10.5281/zenodo.14908511
Keywords:
Talessemiya, saraton, CRISPS Cas9, O'roqsimon hujayrali anemiya, qandli diabet, yurak-qon tomir kasalliklariAbstract
Ushbu tezis CRISPR/Cas9 vositasining biotibbiyot fanlari, xususan, gen terapiyasi sohasidagi qo'llanilishini yoritishga qaratilgan va CRISPR/Cas9 mexanizmi yordamida hal qilinayotgan ko'plab kasalliklarning bir nechtasi bilan bog'liq tushuncha va gen terapiyasi sifatida ushbu dasturning tendentsiyalari, muvaffaqiyatlari va muammolari muhokama qilinadi. CRISPR-Cas9 texnologiyasi gen tahrirlash sohasida inqilobiy yutuq bo‘lib, aniq, samarali va nisbatan arzon usul sifatida genetik muammolarni hal qilishda keng qo‘llanilmoqda. Ushbu texnologiya tibbiyotda irsiy kasalliklarni davolash, saraton terapiyasi, virusli infektsiyalarga qarshi kurash va regenerativ tibbiyotda katta ahamiyat kasb etadi. CRISPR yordamida gen mutatsiyalarini tuzatish, dorilarga chidamlilikni o‘rganish va hujayra terapiyasini takomillashtirish imkoni yaratilmoqda. Shuningdek, texnologiyaning bioetik va xavfsizlik jihatlari ham muhim ahamiyatga ega bo‘lib, ularning tahlili tibbiy amaliyotda CRISPRdan foydalanish imkoniyatlarini yanada kengaytirishga xizmat qiladi. Ushbu ishda CRISPR texnologiyasining tamoyillari, tibbiyotdagi ilovalari va kelajakdagi istiqbollari ko‘rib chiqiladi.
References
Сафарбоева П., Ахтамкулов А., Мустафакулов М. Lipidlar va ularning organizmdagi vazifalari //Новый Узбекистан: наука, образование и инновации. – 2024. – Т. 1. – №. 1. – С. 674-676.
Sh Q. R. et al. Aptomerlar texnologiyasini biotexnologiyada qollash //Interdiscipline innovation and scientific research conference. – 2024. – Т. 3. – №. 26. – С. 67-73.
Mustafoqulov M., Mamadaliyeva Z. TRANSGEN HAYVON OLISH USULLARI //International Journal of Science and Applied Research. – 2024. – T. 1. – Yoʻq. 3. – 78-81-betlar.
Sh Q. R. et al. Aptomerlar texnologiyasini biotexnologiyada qollash //Interdiscipline innovation and scientific research conference. – 2024. – Т. 3. – №. 26. – С. 67-73.
Ilhomova D. O., Sh G. R., Abduvaliyeva M. M. TOZALANMAGAN KOMPLEKS FERMENT PREPARATLARINI OLINISHI: https://doi. org/10.5281/zenodo. 14546817 //International scientific and practical conference. – 2024. – Т. 1. – №. 2. – С. 296-298.
Shamansurova Z. et al. Plasma Insulin level have linkage with neurodegeneration in patients with type 2 DM //Physiology. – 2023. – Т. 38. – №. S1. – С. 5732129.
Uralov A. et al. Building the inflower and realizing seed productivity of A. giganteum regel //E3S Web of Conferences. – EDP Sciences, 2024. – Т. 538. – С. 03020.
Mustafoqulov M. va boshqalar. Mikroorganizmlardan insulinni genetik muhendislik texnologiyasi //Zamonaviy ilmiy va texnik tadqiqotlar xalqaro jurnali. – 2023. – T. 1. – Yoʻq. 2. – 4-12-betlar.
Saatov T. et al. Antioxidant and hypoglycemic effects of gossitan //Endocrine Abstracts. – Bioscientifica, 2019. – Т. 63.
Fattoxova D. Oʻsimlik peroksidaza fermentining biologik ahamiyati: https://doi. org/10.5281/zenodo. 14546269 //International scientific and practical conference. – 2024. – Т. 1. – №. 2. – С. 289-291.
Sh Q. R. et al. Aptomerlar texnologiyasini biotexnologiyada qollash //Interdiscipline innovation and scientific research conference. – 2024. – Т. 3. – №. 26. – С. 67-73.
Ilhomova D. O., Sh G. R., Abduvaliyeva M. M. Tozalanmagan kompleks ferment preparatlarini olinishi: https://doi. org/10.5281/zenodo. 14546817 //International scientific and practical conference. – 2024. – Т. 1. – №. 2. – С. 296-298.
Ishankhodjaev T. et al. Study on Effects of Liposomal Quercetin on Biochemical Parameters of the Nigrostriatal System of Rats with Experimentally Induced Neurodegenerative Disease //Annals of the Romanian Society for Cell Biology. – 2021. – С. 6128-6143.
Mukhammadjon M. et al. The effect of ngf on indicators of the antioxidant system in rat brain tissue //Universum: химия и биология. – 2021. – №. 9 (87). – С. 82-86.
Saatov T. et al. Antioxidant and hypoglycemic effects of gossitan //Endocrine Abstracts. – Bioscientifica, 2019. – Т. 63.
Saatov T. et al. Study on hypoglycemic effect of polyphenolic compounds isolated from the Euphorbia L. plants growing in uzbekistan //Endocrine Abstracts. – Bioscientifica, 2020. – Т. 70.
Saatov T. et al. Correction of oxidative stress in experimental diabetes mellitus by means of natural antioxidants //Endocrine Abstracts. – Bioscientifica, 2021. – Т. 73.
Irgasheva S. et al. Study on compositions of lipids in tissues of rats with alimentary obesity //Endocrine Abstracts. – Bioscientifica, 2019. – Т. 63.
Mamadalieva N. I., Mustafakulov M. A., Saatov T. S. The effect of nerve growth factor on indicators of the antioxidant system in rat brain tissue //eurasian union of scientists. series: medical, biological and chemical sciences Учредители: ООО" Логика+". – 2021. – №. 11. – С. 36-40.
Saatov T. et al. Study on antioxidant and hypoglycemic effects of natural polyphenols in the experimental diabetes model //Endocrine Abstracts. – Bioscientifica, 2018. – Т. 56.
Mustafakulov M. et al. Determination of antioxidant properties of l-cysteine in the liver of alloxan diabetes model rats //International Journal of Contemporary Scientific and Technical Research. – 2023. – №. Special Issue. – С. 47-54.
Мамадалиева Н. И., Мустафакулов М. А., Саатов Т. С. Влияние фактора нервного роста на показатели антиоксидантной системы в тканях мозга крысы //Environmental Science. – 2021. – Т. 723. – С. 022021.
Saatov T. et al. Correction of oxidative stress in experimental diabetes mellitus by means of natural antioxidants //Endocrine Abstracts. – Bioscientifica, 2021. – Т. 73.
Saatov T. et al. Study on hypoglycemic effect of polyphenolic compounds isolated from the Euphorbia L. plants growing in uzbekistan //Endocrine Abstracts. – Bioscientifica, 2020. – Т. 70.
Saatov T. et al. Antioxidant and hypoglycemic effects of gossitan //Endocrine Abstracts. – Bioscientifica, 2019. – Т. 63.
Ishankhodjaev T. et al. Study on Effects of Liposomal Quercetin on Biochemical Parameters of the Nigrostriatal System of Rats with Experimentally Induced Neurodegenerative Disease //Annals of the Romanian Society for Cell Biology. – 2021. – С. 6128-6143.
Saatov T. et al. Neurodegeneration type and severity have linkage with plasma insulin in DM patients //Endocrine Abstracts. – Bioscientifica, 2022. – Т. 81.
Irgasheva S. va boshqalar. TNF-a gen G308A polimorfizmi: 2-toifa qandli diabet bilan og'rigan bemorlarda chastota // Int J Cur Res Rev. – 2020. – T. 2020. – B. 161.
Mustafakulov M. et al. Determination of antioxidant properties of l-cysteine in the liver of alloxan diabetes model rats //International Journal of Contemporary Scientific and Technical Research. – 2023. – №. Special Issue. – С. 47-54.
Shamansurova Z. et al. Plasma Insulin level have linkage with neurodegeneration in patients with type 2 DM //Physiology. – 2023. – Т. 38. – №. S1. – С. 5732129.
Mallayeva M., Mustafakulov M. Toksik gepatitda lipidlarning peroksidalnish mahsulotlariga polifenollarning ta’siri //International Journal of scientific and Applied Research. – 2024. – Т. 1. – №. 3. – С. 75-78.
Uralov A. et al. Building the inflower and realizing seed productivity of A. giganteum regel //E3S Web of Conferences. – EDP Sciences, 2024. – Т. 538. – С. 03020.
Mustafoqulov M. va boshqalar. Mikroorganizmlardan insulinni genetik muhendislik texnologiyasi //Zamonaviy ilmiy va texnik tadqiqotlar xalqaro jurnali. – 2023. – T. 1. – Yoʻq. 2. – 4-12-betlar.
Mustafoqulov M., Mamadaliyeva Z. TRANSGEN HAYVON OLISH USULLARI //International Journal of Science and Applied Research. – 2024. – T. 1. – Yoʻq. 3. – 78-81-betlar.
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