CATARANTHUS ROSEUS ISHLAB CHIQARILADIGAN VINBLASTIN MODDASINI SINTEZLASHDA ZCT GEN OILASI TA'SIRI

https://doi.org/10.5281/zenodo.15174023

Authors

  • Asatova H.S. Toshkent kimyo-texnologiya instituti Author
  • Turayev O. S. O'simliklar genetik resurslari ilmiy-tadqiqot instituti Author
  • Nurmuxamedova V.Z. Toshkent kimyo-texnologiya instituti Author

Keywords:

Cataranthus roseus, ZCT gen oilasi, Vinblastin, Vinkristin, Indol alkaloidlari, STR (Strictosidine synthase), TDC (Tryptophan decarboxylase), va D4H (Desacetoxyvindoline 4-hydroxylase)

Abstract

Cataranthus roseus (Madagaskar pervinkasi) o'simligi tibbiyotda qimmatbaho dori moddalarini ishlab chiqarish uchun asosiy xom ashyo hisoblanadi. Uning tarkibida vinblastin va vinkristin kabi monoterpenoid indol alkaloidlari (MIA) mavjud bo‘lib, ular saraton kasalligini davolashda ishlatiladi. Vinblastin – tabiatda kam uchraydigan va murakkab biosintetik jarayon orqali hosil qilinadigan moddadir. Ushbu jarayonda ZCT (Zinc finger Catharanthus transcription factor) gen oilasi muhim rol o‘ynaydi. Mazkur tezisda vinblastin sintezining molekulyar mexanizmlari va ZCT gen oilasining unga ta’siri tahlil qilinadi.

References

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Published

2025-03-28 — Updated on 2025-04-08

Versions

Issue

Vol. 1 No. 1 (2025): “Biotexnologiyaning rivojlanish istiqbollari va muammolari” mavzusidagi rеspublika ilmiy anjumani

Section

SECTION 1.

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How to Cite

Asatova , H., Turayev , O. S., & Nurmuxamedova , V. (2025). CATARANTHUS ROSEUS ISHLAB CHIQARILADIGAN VINBLASTIN MODDASINI SINTEZLASHDA ZCT GEN OILASI TA’SIRI: https://doi.org/10.5281/zenodo.15174023. International Scientific and Practical Conference, 1(1), 7-8. https://bestjournalup.com/index.php/ispc/article/view/1279