CRISPR-Cas TIZIMI YORDAMIDA XLORELLA (CHLORELLA VULGARIS) GENLARINI TAHRIRLASH VA ULARNING FARMATSEVTIKAGA TADBIQI

https://doi.org/10.5281/zenodo.15179305

Authors

  • Iskandarova F.R Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author
  • Murodova S.S Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author
  • Mamatkulova I.E Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author

Keywords:

CRISPR-Cas9, mikroalgalar, gen tahriri, bioyoqilg‘i, biotexnologiya, Chlorella vulgaris, gen ekspressiyasi, sanoat biotexnologiyasi

Abstract

CRISPR-Cas9 texnologiyasi mikroalgalar genomini aniq tahrirlash uchun istiqbolli vosita bo‘lib, bioyoqilg‘i, farmatsevtika va sanoat uchun muhim xomashyo olish imkonini beradi. Ushbu texnologiya gen ekspressiyasini boshqarish, kerakli biomolekulalar ishlab chiqarishni oshirish va sanoat biotexnologiyasi uchun mikroalgalarni optimallashtirishda samarali bo‘lib, Chlorella vulgaris misolida ko‘rib chiqilgan. Shuningdek, CRISPR orqali gen tahririning samaradorligini oshirish, metabolizmni chuqurroq tushunish va ishlab chiqarish jarayonlarini takomillashtirish zarurati muhokama qilinadi. Mikroalgalarni genetik modifikatsiya qilish orqali bioyoqilg‘i, oziq-ovqat, farmatsevtika va kosmetika sanoatlari uchun yangi istiqbollar ochilmoqda.

References

Patel, V. K., Soni, N., Prasad, V., Sapre, A., Dasgupta, S., & Bhadra, B. (2019). CRISPR–Cas9 System for Genome Engineering of Photosynthetic Microalgae. Molecular Biotechnology, 61(5), 541–561.

Kim, J., Chang, K. S., Lee, S., & Jin, E. (2021). Establishment of a Genome Editing Tool Using CRISPR-Cas9 in Chlorella vulgaris UTEX395. International Journal of Molecular Sciences, 22(2), 480.

Dhokane, D., Shaikh, A., Yadav, A., Giri, N., Bandyopadhyay, A., Dasgupta, S., & Bhadra, B. (2023). CRISPR-based bioengineering in microalgae for production of industrially important biomolecules. Frontiers in Bioengineering and Biotechnology, 11, 1267826.

Bolanos-Martínez, O. C., Malla, A., Rosales-Mendoza, S., & Vimolmangkang, S. (2022). Construction and Validation of a Chloroplast Expression Vector for the Production of Recombinant Proteins in Chlorella vulgaris. Frontiers in Marine Science, 9, 884897.

A.V. Mahmudov O.S. Abduraimov, I.E. Mamatkulova. Structure of local populations and phytocoenotic confinement of Elwendia persica in Turkestan Ridge, Uzbekistan. Biodiversitas. 2023/3., 1621-1628.

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Published

2025-03-28

Issue

Vol. 1 No. 1 (2025): “Biotexnologiyaning rivojlanish istiqbollari va muammolari” mavzusidagi rеspublika ilmiy anjumani

Section

SECTION 1.

License

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Iskandarova , F., Murodova , S., & Mamatkulova , I. (2025). CRISPR-Cas TIZIMI YORDAMIDA XLORELLA (CHLORELLA VULGARIS) GENLARINI TAHRIRLASH VA ULARNING FARMATSEVTIKAGA TADBIQI: https://doi.org/10.5281/zenodo.15179305. International Scientific and Practical Conference, 1(1), 44-46. https://bestjournalup.com/index.php/ispc/article/view/1292