PICHIA PASTORIS ZAMBURUG'I YORDAMIDA FARMATSEVTIK OQSILLARNI ISHLAB CHIQARISHNING INNOVATSION USULLARI
https://doi.org/10.5281/zenodo.15469932
Keywords:
metilotrofik, pichia pastoris, geterologik oqsil, promotor, regulyatsiya, translatsion, sitoxromAbstract
Zamonaviy biotexnologiyada rekombinant oqsillar ishlab chiqarish tibbiyot va farmatsevtika sohasining muhim yo‘nalishlaridan biri hisoblanadi. Pichia pastoris zamburug’i bu jarayonda keng qo‘llaniladigan mikroorganizmlardan biri bo‘lib, u yuqori mahsuldorlik, tez o‘sish va murakkab oqsillarni ishlab chiqarish qobiliyati bilan ajralib turadi. Pichia pastoris (hozirgi nomi Komagataella phaffii) — metilotrof zamburug‘ turi bo‘lib, u metanolni yagona uglerod va energiya manbai sifatida ishlata oladi. 1960-yillarda kashf etilgan ushbu zamburug‘ turi rekombinant oqsillarni ishlab chiqarishda keng qo‘llaniladi. Ushbu tezis Pichia pastoris asosida farmatsevtik oqsillarni ishlab chiqarishning innovatsion usullari ko‘rib chiqiladi.[4]
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References
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