ALSGEYMER KASALLIGINI GEN TERAPIYASI BILAN DAVOLASH
https://doi.org/10.5281/zenodo.15180084
Keywords:
CRISPR-Cas9, EOAD, LOAD, amiloid-b prekursor oqsili, Apolipoprotein E, AAV genomiAbstract
Ushbu tezisda Alsgeymer kasalligi va gen terapiyasi, ayniqsa, CRISPR-Cas9 texnologiyasining davolashdagi roli tahlil qilinadi. Alsgeymer rivojlanishida APP, PSEN1 va PSEN2 genlaridagi mutatsiyalar muhim rol o‘ynaydi. CRISPR yordamida ushbu mutatsiyalarni tuzatish va neyron degeneratsiyasini sekinlashtirish imkoniyatlari ko‘rib chiqiladi. Shuningdek, APOE4 allelini xavfsizroq variantlarga almashtirish va virus vositasida gen yetkazish usullari ham tahlil qilinadi.
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