CRISPR-CAS9 TEXNOLOGIYASINING TIBBIYOTDA QO'LLANILISHI

https://doi.org/10.5281/zenodo.15182320

Authors

  • Abdumalikova S.F. Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author
  • Xolmirzayeva N.O. Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author
  • Ochilova L.K. Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author
  • Soatov B.B. Mirzo Ulug‘bek nomidagi O‘zbekiston Milliy universitetining Jizzax filiali Author

Keywords:

CRISPR-Cas9 texnologiyasi, gen terapiyasi usullari, genetik kasalliklar tashxisi, saraton kasalliklarini davolash, β-talassemiya

Abstract

Hozirgi kunda gen muhandisligida turli yangi texnologiyalar katta ahamiyatga ega bo‘lib bormoqda. Bu texnologiyalar bizga tibbiyot sohasida genetik tahrirlashni amalga oshirish, genetik kasalliklarga samarali davolash usullarini yaratishga imkon yaratmoqda. XXI asrning boshlarida genomni o‘rganish sohasida erishilgan yutuqlar, ayniqsa “Inson genomi” loyihasining muvaffaqiyatli yakunlanishi gen muhandisligi usullarining keng qo‘llanilishiga asos bo‘ldi. Genom tahrirlash sohasidagi eng katta yutuqlardan biri hisoblangan CRISPR/Cas9 texnologiyasi hozirgi kunda tibbiyot sohasida katta o‘zgarishlarni yuzaga keltirmoqda. CRISPR Cas9-texnologiyasi DNKdagi ma’lum qismlarni aniq tahrirlash imkonini beradi va bu jarayonni osonlashtiradi. Bugungi kunda gen terapiyasi usullarining rivojlanishi β-talassemiya, o‘roqsimon hujayrali anemiya kabi genetik kasalliklarni davolashda ijobiy natijalarga erishish imkonini bermoqda.

References

Jennifer A. Doudna va Samuel H. Sternberg. “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution”. Houghton Mifflin Harcourt. Boston New York 2017.

Trionfini P, Ciampi O, Romano E. “CRISPR-Cas9 texnologiyasidan foydalangan holda ikkita izogen nokautli PKD2 iPS hujayra liniyalarini, IRFMNi003-A-1 va IRFMNi003-A-2 ni yaratish”. Stem Cell Res 2020; 42:101667.

Shalem O, Sanjana NE, Zhang F va boshqalar. “CRISPR-Cas9 yordamida yuqori samarali funktsional genomika”. Nat Rev Genet 2015; 16(5):299–311.

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Published

2025-03-28

Issue

Vol. 1 No. 1 (2025): “Biotexnologiyaning rivojlanish istiqbollari va muammolari” mavzusidagi rеspublika ilmiy anjumani

Section

SECTION 1.

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Abdumalikova , S., Xolmirzayeva , N., Ochilova , L., & Soatov , B. (2025). CRISPR-CAS9 TEXNOLOGIYASINING TIBBIYOTDA QO’LLANILISHI: https://doi.org/10.5281/zenodo.15182320. International Scientific and Practical Conference, 1(1), 92-93. https://bestjournalup.com/index.php/ispc/article/view/1310

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