CTLA-4 GENI POLIMORFIZMILARI VA QANDLI DIABETNI ERTA TASHXISLASH

https://doi.org/10.5281/zenodo.15177173

Authors

  • Saidov Z.U. O‘zbekiston Milliy unversitetining Jizzax filiali Author
  • Mustafakulov M.A. Biofizika va biokimyo instituti Author

Keywords:

CTLA-4, 1TQD, PCR, polimorfizm, autoimmune, T-lymphocyte

Abstract

1-turdagi qandli diabet (1TQD) insulin ishlab chiqaruvchi beta hujayralarining yo‘qolishi bilan yuzaga keladigan autoimmun kasallikdir. 1TQD rivojlanishiga genetik va atrof-muhit omillari ta'sir qiladi, bunda immun tizimining noto‘g‘ri ishlashi muhim rol o‘ynaydi. CTLA-4 geni immun tizimining faoliyatini boshqarib, autoimmun kasalliklar, jumladan 1TQDda ham ishtirok etadi. CTLA-4 polimorfizmlari immun tizimidagi o‘zgarishlarga olib kelib, kasallikning rivojlanishiga ta'sir ko‘rsatishi mumkin. Ushbu tadqiqotlar natijasida CTLA-4 polimorfizmlarining autoimmun kasalliklar, ayniqsa, 1-turdagi qandli diabetning rivojlanishidagi o‘rni va ahamiyati to‘g‘risida chuqurroq tushunchaga ega bo‘lish mumkin. CTLA-4 polimorfizmlarining diagnostik marker sifatida ishlatilishi, qandli diabetni erta aniqlash va kasallikning oldini olish uchun yangi yondashuvlarni ishlab chiqishga yordam beradi. Shuningdek, genetik tahlil usullari, masalan, PCR va sekvenatsiya texnologiyalari, CTLA-4 polimorfizmlarini aniqlash va tahlil qilishda samarali qo‘llaniladi, bu esa genetik asosli tashxislashning aniqligini oshiradi.

References

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Obaied M. H. R. et al. Implication of the HLA-DQA1, HLA-DQB1 and CTLA-4 alleles in the susceptibility to type 1 diabetes in Jordanian population //Molecular Biology Reports. – 2025. – Т. 52. – №. 1. – С. 1-8.

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Published

2025-03-28

Issue

Vol. 1 No. 1 (2025): “Biotexnologiyaning rivojlanish istiqbollari va muammolari” mavzusidagi rеspublika ilmiy anjumani

Section

SECTION 1.

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Saidov , Z., & Mustafakulov , M. (2025). CTLA-4 GENI POLIMORFIZMILARI VA QANDLI DIABETNI ERTA TASHXISLASH: https://doi.org/10.5281/zenodo.15177173. International Scientific and Practical Conference, 1(1), 27-29. https://bestjournalup.com/index.php/ispc/article/view/1286

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